A catastrophic drug safety trial which left six healthy volunteers
fighting for their lives with multiple organ failure was the result
of "a powerful pharmacological effect of the product in humans",
found the UK's Medicines and Healthcare products Regulatory Agency.
The "unprecedented reaction" in the first human phase I safety trial
of the drug TGN1412 had not been seen in animal tests at much
higher doses, yet was not due to a dosing error, product
contamination or manufacturing problems.
Click below for the full story on NewScientist.com/news:
http://www.newscientist.com/article/dn8956
So, surprise, suprise, animals and humans do not necessarily react in the same way to drugs. Do you remember thalidomide which was safe on pregnant rodents but not on pregnant women.
I believe that animal testing is fundamentally wrong, and that it's not as useful as some people beleive it is.
